|
| Status |
Public on Sep 22, 2020 |
| Title |
Reciprocal regulation of EGR1 and EZH2 in breast cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found that EGR1 stimulates the expression of EZH2, which in turn inhibited the expression of EGR1 through a silencer region and deletion of the silencer resulted in upregulation of EGR1, which reduced the malignancy of breast cancer cells.
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| |
|
| Overall design |
RNA sequencing of MDA-MB-231 and MCF-7 with wildtype and silencer knockout. Two clones of silencer knockout were included.
|
| |
|
| Contributor(s) |
Guan X, Choi UL, Li G |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 25, 2019 |
| Last update date |
Sep 23, 2020 |
| Contact name |
Gang Li |
| E-mail(s) |
gangli@um.edu.mo
|
| Organization name |
University of Macau
|
| Department |
Faculty of Health Sciences
|
| Lab |
Gang Li's Lab
|
| Street address |
Avenida da Universidade, Taipa
|
| City |
Macau |
| ZIP/Postal code |
999078 |
| Country |
Macau |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA556677 |
| SRA |
SRP216394 |
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