|
| Status |
Public on Jul 31, 2019 |
| Title |
Expression data from murine intrahepatic biliary organoids |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Mutations of isocitrate dehydrogenase (IDH) 1 or 2 occur in 10-30% of intrahepatic cholangiocarcinomas (ICCs). However, their functional roles in biliary carcinogenesis are still unknown.
We used microarrays to investigate how mutant IDH1 affect the gene expression of intrahepatic biliary organoids generated from normal murine liver.
|
| |
|
| Overall design |
By lentiviral techniques, we established murine intrahepatic biliary organoids stably expressing wild-type human IDH1 (IDH1-WT) and mutant human IDH1 (IDH1-MT). Each of them was selected for RNA extraction and hybridization on Affymetrix microarrays.
|
| |
|
| Contributor(s) |
Fujiwara H, Tateishi K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 24, 2019 |
| Last update date |
Aug 03, 2019 |
| Contact name |
Hiroaki Fujiwara |
| E-mail(s) |
hfujiwara29@gmail.com
|
| Phone |
+810336395501
|
| Organization name |
The Institute of Adult Disease, Asahi Life Foundation
|
| Department |
Gastroenterology
|
| Street address |
2-2-6, Bakurocho
|
| City |
Tokyo |
| ZIP/Postal code |
1030002 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (4)
|
| GSM3967071 |
Intrahepatic biliary organoids, IDH1-WT, biological rep1 |
| GSM3967072 |
Intrahepatic biliary organoids, IDH1-WT, biological rep2 |
| GSM3967073 |
Intrahepatic biliary organoids, IDH1-MT, biological rep1 |
| GSM3967074 |
Intrahepatic biliary organoids, IDH1-MT, biological rep2 |
|
| Relations |
| BioProject |
PRJNA556348 |
Less...
More...