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Series GSE134439 Query DataSets for GSE134439
Status Public on Jun 03, 2020
Title Mapping Gata2 enhancer-dependent developmental trajectories by single-cell RNA-sequencing
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We compared single-cell transcriptomes of fetal liver myeloid progenitor pools (CMP/GMP pool) from Gata2 -77 enhancer mutant embryos and wildtype littermates. Gene expression patterns in -77-deficient mice demonstrated loss of erythroid, megakaryocyte and granulocyte progenitors and an increase in monocyte
Overall design Lineage-Sca1-cKit+CD34+ cells from E14.5 fetal livers of two wild type and two -77-deleted embryos were processed for single-cell RNA sequening using 10x Genomics Chromium platform.
Contributor(s) Bresnick EH, Keles S
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Submission date Jul 17, 2019
Last update date Jun 03, 2020
Contact name Emery Bresnick
Organization name University of Wisconsin-Madison
Department Cell and Regenerative Biology
Lab Bresnick Lab
Street address 8457 WIMR 1111 Highland Ave.
City Madison
State/province WI
ZIP/Postal code 53705
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM3946647 Gata2 WT Sample 1
GSM3946648 Gata2 WT Sample 2
GSM3946649 Gata2 -77 enhancer mutant sample 1
BioProject PRJNA555423
SRA SRP215528

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Supplementary file Size Download File type/resource
GSE134439_count_sce_subsamp.csv.gz 14.2 Mb (ftp)(http) CSV
GSE134439_gene_list.csv.gz 12.8 Kb (ftp)(http) CSV
GSE134439_sce.rda.gz 83.7 Mb (ftp)(http) RDA
GSE134439_spring_grouping.csv.gz 1.2 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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