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| Status |
Public on Jun 17, 2020 |
| Title |
Interferon Alpha Induces Multiple Cellular Proteins That Coordinately Suppress Hepadnaviral Covalently Closed Circular DNA Transcription |
| Organism |
Gallus gallus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To identify the cellular genes that mediate IFN-α suppression of cccDNA transcription, the total intracellular RNA were extracted from untreated or recombinant chicken IFN-α (rChIFN-α)-treated cells, and mRNA sequencing (mRNA-Seq) assays were performed in triplicate. And we found that treatment of dstet5 cells with 10 ng/ml of rChIFN-α for 6 h altered the expression of more than 100 cellular genes by more than 2 folds.
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| |
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| Overall design |
mRNA sequencing (mRNA-Seq) assays were performed in triplicate for untreated or rChIFN-α-treated dstet5 cells
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| |
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| Contributor(s) |
Zhou Y, Sheraz M, Chang J, Guo J |
| Citation(s) |
32581092 |
| |
| Submission date |
Jul 16, 2019 |
| Last update date |
Sep 18, 2020 |
| Contact name |
Junjun CHENG |
| E-mail(s) |
junjun.cheng@roche.com
|
| Phone |
(86) 13370219971
|
| Organization name |
Roche Innovation Center (Shanghai)
|
| Department |
Immunology, Infectious Diseases and Ophthalmology (I2O)
|
| Lab |
Infectious Diseases
|
| Street address |
371 Li Shizhen Road, Bldg 5 Pudong
|
| City |
Shanghai |
| ZIP/Postal code |
201203 |
| Country |
China |
| |
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| Platforms (1) |
| GPL19005 |
Illumina HiSeq 2500 (Gallus gallus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA554783 |
| SRA |
SRP214778 |
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