|
| Status |
Public on Jul 12, 2019 |
| Title |
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA-seq analysis of the transcriptome of K562 cells in which PTPN2 or DCAF15 had been disrupted by CRISPR/cas9 gene editing.
|
| |
|
| Overall design |
K562 cells expressing cas9 were infected with lentiviruses expressing sgRNAs against a control gene, PTPN2 or DCAF15. Two weeks after sgRNA infection cells were plated at 0.33M cells/ml and either left alone or treated with 10ng/ml IFNg for 24hrs
|
| |
|
| Contributor(s) |
Pech M, Settleman J |
| Citation(s) |
31452512 |
| |
| Submission date |
Jul 11, 2019 |
| Last update date |
Sep 11, 2019 |
| Contact name |
Linda Fong |
| E-mail(s) |
lindafong@calicolabs.com
|
| Organization name |
Calico Labs
|
| Department |
Oncology
|
| Street address |
1170 Veterans Blvd
|
| City |
South San Francisco |
| State/province |
California |
| ZIP/Postal code |
94080 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (28)
|
|
| Relations |
| BioProject |
PRJNA554137 |
| SRA |
SRP214323 |
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