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Series GSE133355 Query DataSets for GSE133355
Status Public on Jun 27, 2019
Title Bangladeshi women living in UK: Buccal cell DNA methylation analysis
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Prior studies of Bangladeshi migrants in the UK revealed that reproductive function is adaptive, responding to different environments during childhood by adjusting the timing of puberty, reproductive lifespan and overall reproductive function. Here we aimed to understand the basis of this plasticity. Our goals were to establish whether epigenetic mechanisms play a role in the plasticity of this adaptive reproductive phenotype. We hypothesized that women growing up in Bangladesh would have distinct DNA methylation signatures compared to those who moved to the UK at a young age or were born to Bangladeshi parents in the UK. Some of these environmentally induced epigenetic differences would be detected in buccal cell DNA and reflect the divergent gene expression responsible for the altered reproductive function. The women of the study who grew up in Bangladesh were relatively affluent, well-nourished and rarely performed manual work, but a significant confounding factor in their early life was the level of disease load presenting a chronic immune challenge
 
Overall design buccal cell DNA samples from 31 adult Bangladeshi women (age 28.1 ± 5.0) living in London, UK were interogated for their methylation levels using Illumina-MethylationEpic arrays. Sample #12 loaded twice on the array. Quality controls following analysis of the raw data led to the removal of data derived from samples #6, #7 and #10. Usable data: Bangladeshi women experienced their childhoods in Bangladesh (n=15), or in the UK (n=13).
 
Contributor(s) Bar-Sade B, Eden O, Pnueli L, Begum K, Leeman G, Emes RD, Stöger R, Bentley G, Melamed P
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Submission date Jun 26, 2019
Last update date Jun 29, 2019
Contact name Reinhard Stoger
E-mail(s) reinhard.stoger@nottingham.ac.uk
Phone +44 (0)115 951 6232
Organization name Universityf Nottingham
Department School of Biosciences
Lab Stoger-Lab
Street address Sutton Bonington Campus
City Nottingham
ZIP/Postal code LE12 5RD
Country United Kingdom
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (32)
GSM3906148 X201247480032_R01C01: genomic DNA from buccal cells 1
GSM3906149 X201247480032_R02C01: genomic DNA from buccal cells 2
GSM3906150 X201247480032_R03C01: genomic DNA from buccal cells 4
Relations
BioProject PRJNA551254

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE133355_RAW.tar 623.0 Mb (http)(custom) TAR (of IDAT)
GSE133355_TPS5751_RS_EPIC_FFPE_MethylationEPIC_Sample_Sheet_for_Client.xlsx 11.3 Kb (ftp)(http) XLSX
GSE133355_processed_data_sheets.xlsx 7.5 Mb (ftp)(http) XLSX
Processed data provided as supplementary file
Processed data are available on Series record
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