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| Status |
Public on Sep 04, 2020 |
| Title |
The transcription factor Fosl2 controls systemic autoimmunity by repressing FoxP3 during T cell development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: We aimed to charaterise the transfriptional effects of Fosl2 in T cells
Methods: We used wt, Fosl2 overexpressing (Fosl2tg) and Fosl2 knock-out (Fosl2ko) CD4+ naive T cells that we stimulated for 24 hours with anti-CD3 and anti-CD28. RNA-was extracted and sequenced using
Results: We identified a set of genes whose expression is regulated by Fosl2 in T cells, including Foxp3.
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| |
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| Overall design |
RNA-sequencing from T cells with overexpression or knock-out of Fosl2.
|
| |
|
| Contributor(s) |
Renoux F, Distler O |
| Citation(s) |
32610127 |
| |
| Submission date |
Jun 06, 2019 |
| Last update date |
Jan 04, 2021 |
| Contact name |
Oliver Distler |
| E-mail(s) |
oliver.distler@usz.ch
|
| Phone |
+41 44 255 29 70
|
| Organization name |
University Hospital Zurich
|
| Department |
Department of Rheumatology
|
| Street address |
Gloriastrasse 25
|
| City |
Zurich |
| ZIP/Postal code |
8091 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (9)
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| Relations |
| BioProject |
PRJNA547589 |
| SRA |
SRP200662 |
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