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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 09, 2009 |
| Title |
Effect of age on the arthritis susceptibility of BALB/c mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Rheumatoid arthritis (RA) usually begins in females in their 4th-5th decade, suggesting that the aging of the immune system (immunosenescence) has a major impact on this disease.
In the present microarray study, we set out to identify age- and arthritis-related gene expression pattern changes in proteoglycan (aggrecan)-induced arthritis (PGIA) model.
Keywords: disease state analysis
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| Overall design |
We compared the gene expression profile of spleens from PG-immunized but non-arthritic old (older than 4 months) and young (1 month old) mice, and then made a comparison between non-arthritic and age-matched arthritic mice.
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| Contributor(s) |
Boldizsar F, Tarjanyi O, Glant TT, Larsen P, Laszlo A |
| Citation(s) |
19519881 |
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| Submission date |
Oct 10, 2008 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Tibor T Glant |
| E-mail(s) |
Tibor_Glant@rush.edu
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| Organization name |
Rush University Medical Center
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| Department |
Orthopedic Surgery
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| Lab |
Molecular Medicine
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| Street address |
1735 West Harrison
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60612 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (10)
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| GSM329261 |
spleen, old, arthritic, biological replicate 1 |
| GSM329262 |
spleen, old, arthritic, biological replicate 2 |
| GSM329263 |
spleen, old, non-arthritic, biological replicate 1 |
| GSM329264 |
spleen, old, non-arthritic, biological replicate 2 |
| GSM329265 |
spleen, young, arthritic, biological replicate 1 |
| GSM329266 |
spleen, young, arthritic, biological replicate 2 |
| GSM329267 |
spleen, young, non-arthritic, biological replicate 1 |
| GSM329268 |
spleen, young, non-arthritic, biological replicate 2 |
| GSM329269 |
spleen, young, non-arthritic, biological replicate 3 |
| GSM329270 |
spleen, young, non-arthritic, biological replicate 4 |
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| Relations |
| BioProject |
PRJNA109725 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE13148_RAW.tar |
40.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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