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Series GSE130871 Query DataSets for GSE130871
Status Public on Dec 20, 2019
Title Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
Organisms Callithrix jacchus; Macaca mulatta; Pan troglodytes; Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which of these changes are biologically relevant and underlie the emergence of the human brain or its unique susceptibility to neural disease has been challenging. Here we annotate changes to gene regulatory elements at cell type resolution in the brains of multiple primate species spanning most of primate evolution. We identify a unique set of regulatory elements that emerged in hominins prior to the separation of humans and chimpanzees. We demonstrate that these hominin gains disproportionally affect oligodendrocyte function after postnatal development and are preferentially affected in the brains of autism spectrum disorder patients. Our data provide a roadmap of regulatory rewiring across primate evolution providing insight into the genomic changes that underlie the emergence of the brain and its susceptibility to neural disease.
Overall design ChIP-sequencing for H3K27ac, ATAC-sequencing and RNA-sequencing of primate brain samples
Contributor(s) Castelijns B, Baak ML, Timpanaro IS, Wiggers CR, Vermunt MW, Shang P, Kondova I, Bianci V, de Laat W, Geijsen N, Creyghton MP
Citation(s) 31949148
Submission date May 08, 2019
Last update date Jan 27, 2020
Contact name Menno P Creyghton
Organization name Hubrecht Institute
Lab Creyghton
Street address Uppsalalaan 8
City Utrecht
ZIP/Postal code 3584 CT
Country Netherlands
Platforms (6)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL17712 Illumina HiSeq 2000 (Callithrix jacchus)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (49)
GSM3755466 Marmoset_Cerebellum_H3K27ac_1
GSM3755467 Marmoset_Cerebellum_H3K27ac_2
GSM3755468 Marmoset_Cerebellum_H3K27ac_3
BioProject PRJNA541855
SRA SRP197043

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Supplementary file Size Download File type/resource
GSE130871_RAW.tar 6.6 Gb (http)(custom) TAR (of BW, NARROWPEAK, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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