GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE130647 Query DataSets for GSE130647
Status Public on May 01, 2020
Title Pathway analysis of miRNA revealing immunologic alteration in lymphocyte immune response and T cell differentiation in Fontan patients with protein-losing enteropathy
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Protein losing enteropathy (PLE) is a severe complication of Fontan circulation with increased morbidity and mortality. The underlying pathophysiologic mechanism leading to the development of PLE in Fontan patients remain largely unknown. We performed microarray-based microRNA (miRNA) expression profiling from whole blood to generate hypotheses about relevant pathways involved in PLE pathogenesis controlled by miRNA signature.
Overall design RNA was extracted of whole blood samples (PAXgene tubes) of 46 patients (n=10 Fontan patients with PLE, n=28 Fontan patients without PLE and n=8 patients with dextro tansposition of the great arteries (d-TGA). The miRNA microarray expression analysis was performed on GeneChip miRNA 4.1 microarray.
Contributor(s) Ekici AB, Moosmann J
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date May 02, 2019
Last update date May 03, 2020
Contact name Arif B Ekici
Organization name Institute of Human Genetics
Street address Schwabachanlage 10
City Erlangen
ZIP/Postal code 91054
Country Germany
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (46)
GSM3746216 Pat_2_tga
GSM3746217 Pat_3_non-PLE
GSM3746218 Pat_4_PLE
BioProject PRJNA540866

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE130647_RAW.tar 35.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap