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| Status |
Public on May 01, 2020 |
| Title |
Pathway analysis of miRNA revealing immunologic alteration in lymphocyte immune response and T cell differentiation in Fontan patients with protein-losing enteropathy |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Protein losing enteropathy (PLE) is a severe complication of Fontan circulation with increased morbidity and mortality. The underlying pathophysiologic mechanism leading to the development of PLE in Fontan patients remain largely unknown. We performed microarray-based microRNA (miRNA) expression profiling from whole blood to generate hypotheses about relevant pathways involved in PLE pathogenesis controlled by miRNA signature.
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| Overall design |
RNA was extracted of whole blood samples (PAXgene tubes) of 46 patients (n=10 Fontan patients with PLE, n=28 Fontan patients without PLE and n=8 patients with dextro tansposition of the great arteries (d-TGA). The miRNA microarray expression analysis was performed on GeneChip miRNA 4.1 microarray.
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| Contributor(s) |
Ekici AB, Moosmann J |
| Citation missing |
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| |
| Submission date |
May 02, 2019 |
| Last update date |
May 03, 2020 |
| Contact name |
Arif B Ekici |
| E-mail(s) |
arif.ekici@uk-erlangen.de
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| Organization name |
Institute of Human Genetics
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| Street address |
Schwabachanlage 10
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| City |
Erlangen |
| ZIP/Postal code |
91054 |
| Country |
Germany |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (46)
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| Relations |
| BioProject |
PRJNA540866 |
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