|
| Status |
Public on Apr 18, 2019 |
| Title |
RNA sequencing in kidneys of MUC1 Kidney Disease mouse model with and without treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
MUC1 kidney disease mouse model generated by knock-in of the human mutated MUC1-fs gene. The mice were treated for 7 days, daily with either vehicle control or BRD4780, a compound showed to be beneficial to disease cells in-vitro. The kidneys were then removed and the bulk RNA was sequenced. The goal of this study was to undersand the effect of the compound on the diseased kidneys and to gain insights to its mechanism of action.
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| |
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| Overall design |
MUC1 kidney disease mouse models in quatriplate were treated with either vehicle or BRD4780 daily for 7 days, followed by kidney removal, RNA isolation and bulk RNA sequencing
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| |
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| Contributor(s) |
Levitt MD, Kohnert E |
| Citation(s) |
31348885 |
| |
| Submission date |
Apr 17, 2019 |
| Last update date |
Aug 28, 2019 |
| Contact name |
Moran Dvela Levitt |
| E-mail(s) |
dvelamo@broadinstitute.org
|
| Organization name |
Broad Institute
|
| Lab |
Greka Lab
|
| Street address |
415 Main Street
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE129971 |
Small molecule targets TMED9, promotes lysosomal degradation to reverse proteinopathy |
|
| Relations |
| BioProject |
PRJNA533238 |
| SRA |
SRP192832 |
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