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| Status |
Public on Mar 12, 2020 |
| Title |
Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Comparison of Clinical and Biological Responses to Cat Allergen |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
A direct comparison of NAC and EEC allergen challenges revealed differences in the kinetics and magnitude of clinical responses, but comparable immunological responses indicating similarity in the biological pathways elicited by both challenge methodologies
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| Overall design |
Nasal brushing samples collected from ITN cat allergic individuals at baseline (prior to allergen exposure), 8 hours after nasal allergen challenge (NAC) exposure, and 8 hours after environmental exposure challenge (EEC). Cross over study design
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| Contributor(s) |
Larson D, Patel P, Salapatek A, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James EA, French DR, Lelic A, Larché M, Altman MC, Togias A, Durham SR |
| Citation(s) |
32169380 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| UM1 AI109565 |
Immune Tolerance Network |
BENAROYA RESEARCH INSTITUTE |
GERALD T NEPOM |
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| Submission date |
Apr 12, 2019 |
| Last update date |
Jun 11, 2020 |
| Contact name |
Tielin Qin |
| E-mail(s) |
tqin@immunetolerance.org
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| Phone |
2402356139
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| Organization name |
Immune Tolerance Network
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| Street address |
7500 Old Georgetown Road, Suite 800
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20814 |
| Country |
USA |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (65)
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| Relations |
| BioProject |
PRJNA532625 |
| SRA |
SRP192408 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE129748_P197-1_CB6GMANXX_171009_combined_counts.csv.gz |
772.2 Kb |
(ftp)(http) |
CSV |
| GSE129748_P197-1_CB7GFANXX_170912_combined_counts.csv.gz |
1.9 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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