|
| Status |
Public on Apr 03, 2019 |
| Title |
Defining DC response to cognate T cell interaction in the antigen-challenged lymph node [dataset 3] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We designed an experimental set up to probe DC responses to cognate T cell encounter in antigen draining LN
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| |
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| Overall design |
We immunized mice that had been engrafted with antigen-specific T cells (OT-I, OT-II), with nanoparticles (NP) entrapping antigen (OVA), adjuvants (CpG) and a fluorescent dye (6G rhodamine) to study the immediate DC response to T cell encounter using bulk and single cell RNA-seq profiling.
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| |
|
| Contributor(s) |
Curato C, Chappell-Maor L, David E, Jung S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Apr 02, 2019 |
| Last update date |
Apr 03, 2019 |
| Contact name |
Steffen Jung |
| E-mail(s) |
s.jung@weizmann.ac.il
|
| Phone |
0097289342787
|
| Organization name |
The Weizmann Institute of Science
|
| Department |
Immunology and Regenerative Biology
|
| Lab |
Steffen Jung
|
| Street address |
Herzl
|
| City |
REHOVOT |
| ZIP/Postal code |
76100 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (39)
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| This SubSeries is part of SuperSeries: |
| GSE129215 |
IL-23 producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven pro-inflammatory epithelial cell response |
|
| Relations |
| BioProject |
PRJNA530542 |
| SRA |
SRP190165 |
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