|
| Status |
Public on Apr 03, 2019 |
| Title |
RNA sequencing of WT and AICDA KO iPCS clones |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report AICDA facilitates naïve pluripotency of mouse iPSCs by suppressing FGF/ERK signaling. In the absence of AICDA iPSCs fail to achive naïve pluripotent state and display chracteristics of EpiSCs and are primed for differentiation.
|
| |
|
| Overall design |
IPSC clones from WT and AICDA KO fibroblasts were reprogrammed using OSKM.
|
| |
|
| Contributor(s) |
Kumar R, Evans T |
| Citation(s) |
31021461 |
| |
| Submission date |
Apr 02, 2019 |
| Last update date |
Oct 08, 2019 |
| Contact name |
Ritu Kumar |
| E-mail(s) |
rik2002@med.cornell.edu
|
| Organization name |
Weill Cornell Medicine
|
| Department |
Surgery
|
| Street address |
1300 York Avenue
|
| City |
New York |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (6)
|
|
| This SubSeries is part of SuperSeries: |
| GSE129223 |
The Cytosine Deaminase AICDA Regulates FGF/ERK Signaling to Achieve the Naïve Pluripotent State During Reprogramming. |
|
| Relations |
| BioProject |
PRJNA530409 |
| SRA |
SRP190136 |
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