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Series GSE128451 Query DataSets for GSE128451
Status Public on Mar 19, 2019
Title Expression data of lung tissues of rats exposed to chronic hypoxia
Platform organism synthetic construct
Sample organism Rattus norvegicus
Experiment type Non-coding RNA profiling by array
Summary Under hypoxic exposure in rats, activation of VEGF/Notch pathway may lead to pulmonary angiogenesis, and the expression of related proteins may be associated with down-regulation of miRNAs.
We used microarrays to screen out miRNAs related to VEGF/Notch pathway in hypoxic exposure, and in this process, we found genes with a downregulation trend with prolonged exposure time.
 
Overall design Lung tissues of male SD rats were selected for RNA extraction and hybridization on Affymetrix microarrays. In order to further screen out hypoxia genes related to VEGF/Notch pathway and explore their tendency and downregulation with the increase of hypoxia exposure time. To this end, rats were divided into the normoxic control group (C)h and the rat exposure time of 24 hours (H_24), 48 hours (H_48) and 72 hours (H_72) groups.
 
Contributor(s) Ding H, Fan H
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Submission date Mar 18, 2019
Last update date Mar 20, 2019
Contact name Wei Cai
E-mail(s) 15182987332@163.com
Organization name School of disaster medical research´╝îTianjin University
Street address No. 92 Weijin Road, Nankai District
City Tianjin
ZIP/Postal code 300162
Country China
 
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (12)
GSM3675873 C_1: Lung_hypoxia_0hr_rep1
GSM3675874 C_2: Lung_hypoxia_0hr_rep2
GSM3675875 C_3: Lung_hypoxia_0hr_rep3
Relations
BioProject PRJNA527784

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE128451_RAW.tar 7.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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