|
| Status |
Public on Apr 03, 2019 |
| Title |
A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
These observations identify SOD3 as a relevant drug target, and BNTA as a potential therapeutic agent in osteoarthritis.
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| |
|
| Overall design |
Examination a disease-modifying OA drugs and its molecular target.
Case: Cartilage tissues were collected from medial and lateral femoral condyles of anterior cruciate ligament transection-operated rat knee joints treated with BNTA (1.5 mg kg-1) twice a week for 4 w.
Control: Cartilage tissues were collected from medial and lateral femoral condyles of anterior cruciate ligament transection-operated rat knee joints treated with normal saline (vehicle) twice a week for 4 w.
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| |
|
| Contributor(s) |
Ao Y, Shi Y |
| Citation(s) |
31015473 |
| |
| Submission date |
Mar 11, 2019 |
| Last update date |
May 02, 2019 |
| Contact name |
shi yuanyuan |
| E-mail(s) |
shiyuanyuan815@163.com
|
| Organization name |
Peking University
|
| Street address |
No.5 Yiheyuan Road Haidian District, Beijing, P.R.China
|
| City |
Beijing |
| State/province |
Bejing |
| ZIP/Postal code |
100871 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24688 |
HiSeq X Ten (Rattus norvegicus) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA526447 |
| SRA |
SRP188077 |
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