|
| Status |
Public on Jan 07, 2020 |
| Title |
TRAP from CA1 pyramidal neurons and cerebellar granule cells in Fmr1 KO and wildtype mice |
| Organism |
Mus musculus |
| Experiment type |
Other
|
| Summary |
TRAP (translating ribosome affinity purification) from CA1 pyramidal neurons and cerebellar granule cells in wildtype and Fmr1 KO littermate pairs. These data show a global downregulation of FMRP targets in Fmr1 KO mice in these cell types.
|
| |
|
| Overall design |
TRAP (translating ribosome affinity purification) from CA1 pyramidal neurons and cerebellar granule cells. For each cell type, 3 biological replicates of total mRNA (input) from WT and Fmr1 KO littermate pairs and ribosome-bound transcripts (TRAP) from the same animals were sequencing.
|
| |
|
| Contributor(s) |
Sawicka K, Darnell RB, Darnell JC |
| Citation(s) |
31860442 |
| |
| Submission date |
Mar 05, 2019 |
| Last update date |
Jan 07, 2020 |
| Contact name |
Kirsty Sawicka |
| E-mail(s) |
Kirsty.sawicka@cruk.cam.ac.uk
|
| Organization name |
CRUK Cambridge Insititute
|
| Department |
University of Cambridge
|
| Street address |
Robinson Way
|
| City |
Cambridge |
| ZIP/Postal code |
CB2 0RE |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (24)
|
|
| This SubSeries is part of SuperSeries: |
| GSE127847 |
The Fragile X protein, FMRP, has a cell-type specific role in CA1 hippocampal neurons to regulate transcripts encoding autism-spectrum proteins and circadian memory |
|
| Relations |
| BioProject |
PRJNA525640 |
| SRA |
SRP187543 |
Less...
More...