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Series GSE126958 Query DataSets for GSE126958
Status Public on Apr 21, 2020
Title Genome-wide methyl-cytosine competition by DNMT and TET
Organisms Homo sapiens; Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary We define distinct methylated elements that recruit both DNMT3A/B and TETs. We also show the genome-wide activity of DNMTs and TETs.
Overall design We performed WGBS for a series of HUES64 and HUES8 human embryonic stem cells: wildtype (WT), DNMT3A and DNMT3B double knockout (DKO), TET triple knockout (TKO), TKO plus DNMT3B knockout (QKO) and QKO plus DNMT3A knockout (PKO). We also performed bulk RNA sequencing.
Contributor(s) Charlton J, Meissner A
Citation(s) 32514123
Submission date Feb 22, 2019
Last update date Jul 21, 2020
Contact name Jocelyn Charlton
Organization name Harvard University
Department Stem Cell and Regenerative Biology
Lab Meissner Lab
Street address 7 Divinity Avenue
City Cambridge
State/province MA
ZIP/Postal code 02138
Country USA
Platforms (4)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (42)
BioProject PRJNA523851
SRA SRP186642

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE126958_RAW.tar 7.1 Gb (http)(custom) TAR (of BED, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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