|
| Status |
Public on Feb 20, 2021 |
| Title |
Targeting PDGFRa-activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
SHP-2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is critical for PDGFR-driven gliomagenesis. SHP099, a novel and potent SHP-2 inhibitor, preferentially attenuated the tumorigenicity of GBM and glioma stem-like cells (GSCs) compared to normal brain cells or neural progenitor cells in vitro. Delivered orally, SHP099 crosses the blood-brain barrier (BBB) and accumulates at efficacious concentrations in the brains, as determined using two different orthotopic xenograft models. SHP099 inhibited tumor growth and extended survival in activated PDGFR-signaling xenografts alone and in combination with first-line chemotherapeutic agent, temozolomide (TMZ). This study highlights SHP-2 inhibitor SHP099 potential for treatment of clinical GBM in combination with TMZ.
|
| |
|
| Overall design |
Examination of effects of SHP-2 inhibitor SHP099 treatment on differential gene expression in glioma cells.
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| |
|
| Contributor(s) |
Feng H |
| Citation(s) |
31232447 |
| |
| Submission date |
Feb 21, 2019 |
| Last update date |
May 23, 2021 |
| Contact name |
Haizhong Feng |
| E-mail(s) |
fenghaizhong@sjtu.edu.cn
|
| Phone |
862168383921
|
| Organization name |
Shanghai Jiao Tong University
|
| Department |
Ren Ji Hospital
|
| Street address |
Pujian Road 160
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200127 |
| Country |
China |
| |
|
| Platforms (1) |
|
| Samples (6)
|
| GSM3617816 |
Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S9_L006] |
| GSM3617817 |
Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S9_L007] |
| GSM3617818 |
Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S10_L006] |
| GSM3617819 |
Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S10_L007] |
| GSM3617820 |
Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S11_L006] |
| GSM3617821 |
Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S11_L007] |
|
| Relations |
| BioProject |
PRJNA523607 |
| SRA |
SRP186500 |
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