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Series GSE126892 Query DataSets for GSE126892
Status Public on Feb 20, 2021
Title Targeting PDGFRa-activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary SHP-2 is a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene and is critical for PDGFR-driven gliomagenesis. SHP099, a novel and potent SHP-2 inhibitor, preferentially attenuated the tumorigenicity of GBM and glioma stem-like cells (GSCs) compared to normal brain cells or neural progenitor cells in vitro. Delivered orally, SHP099 crosses the blood-brain barrier (BBB) and accumulates at efficacious concentrations in the brains, as determined using two different orthotopic xenograft models. SHP099 inhibited tumor growth and extended survival in activated PDGFR-signaling xenografts alone and in combination with first-line chemotherapeutic agent, temozolomide (TMZ). This study highlights SHP-2 inhibitor SHP099 potential for treatment of clinical GBM in combination with TMZ.
Overall design Examination of effects of SHP-2 inhibitor SHP099 treatment on differential gene expression in glioma cells.
Contributor(s) Feng H
Citation(s) 31232447
Submission date Feb 21, 2019
Last update date May 23, 2021
Contact name Haizhong Feng
Phone 862168383921
Organization name Shanghai Jiao Tong University
Department Ren Ji Hospital
Street address Pujian Road 160
City Shanghai
State/province Shanghai
ZIP/Postal code 200127
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (6)
GSM3617816 Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S9_L006]
GSM3617817 Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S9_L007]
GSM3617818 Ink4a/Arf-/-/PDGFRa/PDGF-A [R17023449LR01_S10_L006]
BioProject PRJNA523607
SRA SRP186500

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Supplementary file Size Download File type/resource
GSE126892_RAW.tar 9.1 Mb (http)(custom) TAR (of XLSX)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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