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| Status |
Public on Feb 26, 2019 |
| Title |
miR-19 protects heart from myocardium infarction |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The adult heart has been considered as an organ with limited regenerating capability due to mature cardiomyocytes exit the cell cycle and stop proliferating. It has been reported that miR-17-92 cluster plays a key role in cardiomyocyte proliferation. According to the seed sequence, miR-17-92 cluster includes miR-18, miR-19, miR-20 and miR-92 families. Here, we show that intra-cardiac injection of miR-19 mimic into adult mouse hearts protects heart from myocardial infarction injury with reduced apoptosis, enhanced cardiomyocyte proliferation and cardiac regeneration. We performed the RNA-seq profiling in both injection of control mimic and miR-19 mimic post myocardial infarction. The transcriptome analysis indicates that genes related to immune response and cardiac remodeling were repressed by miR-19 in infarcted hearts.
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| Overall design |
Examine expression of mRNAs in control mimic and miR-19 mimic injected hearts after myocardium infarction
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| |
|
| Contributor(s) |
Chen J, Wang D |
| Citation(s) |
30996254 |
| |
| Submission date |
Feb 21, 2019 |
| Last update date |
May 30, 2019 |
| Contact name |
Jinghai Chen |
| E-mail(s) |
jinghaichen@zju.edu.cn
|
| Phone |
86-15869114168
|
| Organization name |
Zhejiang University
|
| Department |
Institute of Translational Medicine
|
| Street address |
268 Kai-Xuan Road, North Central Building 540
|
| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
310029 |
| Country |
China |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA523604 |
| SRA |
SRP186494 |
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