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Series GSE12682 Query DataSets for GSE12682
Status Public on Apr 13, 2010
Title Expression data from Human Kidney (HK) samples
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Males are 50% more likely to develop end stage kidney failure compared to women. In this study we wanted to find out the molecular mechanism responsible for this increased risk. We collected kidney samples from patients with and without kidney disease and performed a comprehensive gene expression analysis in healthy and diseased male and female kidneys.
Interestingly, the set of gender biased genes in healthy kidneys were different from those in diseased kidneys indicating not only baseline gene expression differences but also that the male and female kidney respond differently to disease condition. Our studies indicate that men and women with kidney problems might need to be treated differently.

Keywords: Gender difference
 
Overall design We collected 42 kidney samples from healthy living transplant donors, nephrectomies and from diagnostic kidney biopsies. Preliminary studies did not show significant gene expression differences in control kidneys based on the collection method (i.e. living kidney biopsy vs. unaffected portion of tumor nephrectomy). We grouped the tissue samples based on the histological readings of the kidney biopsies. Samples with evidence of glomerular and tubulointerstitial fibrosis were assigned into the diseased group. Characteristics of the research participants indicate diverse ethnic and disease groups and mild (StageIII) CKD. The tissue was microdissected into glomerular and tubulointerstitial fractions and expression arrays were performed separately.
 
Contributor(s) Susztak K, Si H
Citation(s) 19277126
Submission date Sep 05, 2008
Last update date Dec 06, 2018
Contact name Han Si
E-mail(s) hsi@aecom.yu.edu
Organization name AECOM
Department Medicine/Nephrology
Lab Susztak, Katalin MD, PhD
Street address 1300 Morris Park
City Bronx
State/province NY
ZIP/Postal code 10461
Country USA
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (52)
GSM318464 Male human kidney sample No.37 glomeruli fraction
GSM318465 Male human kidney sample No.50 glomeruli fraction
GSM318466 Male human kidney sample No.77 glomeruli fraction
Relations
BioProject PRJNA112681

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12682_RAW.tar 108.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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