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| Status |
Public on Sep 15, 2019 |
| Title |
ZRANB2 and SYF2 mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We explored the regulation of alternative splicing in a cell model of breast cancer resistance to doxorubicin, and the impact of the depletion of two splicing factors (ZRANB2 and SYF2) in this context.
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| Overall design |
We analyzed by RNA-seq, alternative splicing regulation between doxorubicin-resistant and sensitive cells, and between resistant cells with ot without depletion of either ZRANB2 or SYF2 (2 independent siRNAs for each, all conditions in triplicate).
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| Contributor(s) |
DUTERTRE M, TANAKA I, CHAKRABORTY A, SAULNIER O, BENOIT-PILVEN C, VACHER S, LAM EW, BIECHE I, DELATTRE O, AUBOEUF D, VAGNER S |
| Citation(s) |
31943118 |
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| Submission date |
Feb 11, 2019 |
| Last update date |
Jan 17, 2020 |
| Contact name |
jean-baptiste claude |
| E-mail(s) |
jean-baptiste.claude@ens-lyon.fr
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| Phone |
+33 4 72 72 81 71
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| Organization name |
[CNRS/ENS Lyon/UCBL/HCL] Laboratoire de Biologie Moléculaire de la Cellule UMR5239
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| Street address |
46, allée d’Italie
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| City |
Lyon |
| ZIP/Postal code |
69364 |
| Country |
France |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA521712 |
| SRA |
SRP185438 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE126365_RAW.tar |
9.0 Gb |
(http)(custom) |
TAR (of BEDGRAPH, BW) |
| GSE126365_Splicing-MCF7_DoxoR_siCtl-vs-MCF7_DoxoR_siSYF2_si1.xls.gz |
24.6 Kb |
(ftp)(http) |
XLS |
| GSE126365_Splicing-MCF7_DoxoR_siCtl-vs-MCF7_DoxoR_siSYF2_si2.xls.gz |
37.6 Kb |
(ftp)(http) |
XLS |
| GSE126365_Splicing-MCF7_DoxoR_siCtl-vs-MCF7_DoxoR_siZRANB2_si1.xls.gz |
37.5 Kb |
(ftp)(http) |
XLS |
| GSE126365_Splicing-MCF7_DoxoR_siCtl-vs-MCF7_DoxoR_siZRANB2_si2.xls.gz |
14.7 Kb |
(ftp)(http) |
XLS |
| GSE126365_Splicing-MCF7_DoxoR_siCtl-vs-MCF7_siCtl.xls.gz |
294.6 Kb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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