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| Status |
Public on Aug 01, 2019 |
| Title |
Small RNA profiling in mouse alcohol-induced liver injury and steatosis model. |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system.here we demonstrate protection in wild type mice by treatment with CR2-Crry, a C3 inhibitor that specifically targets sites of complement activation. We found that the expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice, and that inhibition of Gly-tRFs in vivo decreases chronic ethanol-feeding-induced hepatosteatosis without affecting inflammation
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| |
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| Overall design |
small RNAs expression profiling of liver tissues obtained after 16 days EtOH feed.
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| Contributor(s) |
He S, Zhong F |
| Citation(s) |
31076642 |
| |
| Submission date |
Feb 04, 2019 |
| Last update date |
Oct 29, 2019 |
| Contact name |
Songqing He |
| E-mail(s) |
zyl-lian@163.com
|
| Organization name |
Guangxi Medical University
|
| Street address |
No.22 Shuangyong road
|
| City |
Guangxi |
| ZIP/Postal code |
530021 |
| Country |
China |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA520870 |
| SRA |
SRP183465 |
