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| Status |
Public on Jul 25, 2019 |
| Title |
Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using RNA-seq we identified several genes downstream of p110α in the trophoblast that are important in adapting placental phenotype to support fetal growth.
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| Overall design |
This was achieved by comparing the transcriptomes of 5 Het-U (heterozygous deficient in p110α in both fetal and trophoblast lineages) and 4 Hom-P (heterozygous deficient in p110α in fetal lineage and homozygous deficient in p110α in trophoblast) placentas placentas at day 19 of pregnancy.
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| Contributor(s) |
Lopez-Tello J, Perez-Garcia V, Khaira J, Kusinski LC, Cooper WN, Andreani A, FernandezdeLiger E, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN |
| Citation(s) |
31241463 |
| |
| Submission date |
Feb 04, 2019 |
| Last update date |
Jul 25, 2019 |
| Contact name |
Brian Yee Hong Lam |
| E-mail(s) |
yhbl2@cam.ac.uk
|
| Organization name |
University of Cambridge
|
| Department |
Metabolic Research Laboratories
|
| Street address |
Box 289 Addenbookes Hospital, Hills Road
|
| City |
Cambridge |
| ZIP/Postal code |
CB2 0QQ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA520850 |
| SRA |
SRP183456 |
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