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| Status |
Public on Jan 03, 2019 |
| Title |
Expression changes in the prefrontal cortex after neurotransmission blocking of nucleus accumbens pathways |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
GSEA using both edgeR and voom statistics revealed that the ES of two types of corticothalamic neurons, CTX.Glt25d2-positive layer 5b and CTX.Ntsr1-positive layer 6 neurons, were downregulated by both NAc D1- and D2-RNB. In contrast, the ES of CTX.S100a10 corticostriatal neurons were upregulated and downregulated by NAc D1- and D2-RNB, respectively. These data show that cortical neurons are asymmetrically regulated by subcortical pathways in the mPFC-NAc-VP/SNr-MD/VD-mPFC circuit.
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| |
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| Overall design |
mPFC mRNA profiles of the NAc D1- or D2-RNB mice
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| |
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| Contributor(s) |
Yao S, Hikida T, Macpherson T, Morita M, Fukakusa A, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A |
| Citation(s) |
32020036 |
| |
| Submission date |
Jan 02, 2019 |
| Last update date |
Feb 14, 2020 |
| Contact name |
Shuhei Yao |
| Organization name |
Takeda pharmaceutical company LTD.
|
| Street address |
Muraokahigashi2-26-1
|
| City |
Fujisawa-city |
| State/province |
Kanagawa |
| ZIP/Postal code |
251-0012 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA512534 |
| SRA |
SRP175045 |
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