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| Status |
Public on Jan 02, 2022 |
| Title |
A wave of Foxp3 + regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The liver in newborn animals undergo a maturation process in order to adapt to a plethora of changes and challenges in the extra-uterine life. The influx of regulatory T cells during 1-2-week period protect the animals from autoimmune hepatitis and govern the transformation of a neonatal liver to a crucial metabolic organ in adults.
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| Overall design |
CD4+GFP+ Treg cells from the liver and spleen of Foxp3GFP knock-in mice (12-day-old) were purified by flow cytometry.
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| Contributor(s) |
Li M, Zhang K, Ge Q |
| Citation(s) |
31171863 |
| |
| Submission date |
Jan 02, 2019 |
| Last update date |
Apr 03, 2022 |
| Contact name |
Kunshan Zhang |
| E-mail(s) |
zhangkunshan@tongji.edu.cn
|
| Organization name |
Tongji University
|
| Department |
Tongji Hospital
|
| Lab |
Translational Stem Cell Research Center
|
| Street address |
389 Xincun Rd.
|
| City |
Shanghai |
| ZIP/Postal code |
200064 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA512452 |
| SRA |
SRP174990 |
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