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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 19, 2019 |
| Title |
Analysis of transcriptome changes following SOX2 knockdown in three different Ewing sarcoma cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report that knockdown of SOX2 in Ewing sarcoma cell lines promotes changes in the expression of several genes that are involved a variety of molecular processes.
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| Overall design |
RNA-seq of three Ewing sarcoma cell lines (EW1, RDES, POE), transiently transfected with a non-targeting control siPOOL or two different specific siPOOLs targeting SOX2.
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| Contributor(s) |
Sannino G, Da Silveira W, Hardiman G, Grünewald TG |
| Citation(s) |
31427232 |
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| Submission date |
Dec 20, 2018 |
| Last update date |
Nov 18, 2019 |
| Contact name |
Thomas Georg Philipp Grunewald |
| E-mail(s) |
t.gruenewald@kitz-heidelberg.de
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| Phone |
0049-6221-423718
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| Organization name |
German Cancer Research Center (DKFZ)
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| Department |
Division of Translational Pediatric Sarcoma Research
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| Street address |
Im Neuenheimer Feld 280
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| City |
Heidelberg |
| ZIP/Postal code |
69120 |
| Country |
Germany |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (18)
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| GSM3525936 |
EW1_siCTR_split1, technical replicate, 72h |
| GSM3525937 |
EW1_siCTR_split2, technical replicate, 72h |
| GSM3525938 |
EW1_siPool_1_split1, technical replicate, 72h |
| GSM3525939 |
EW1_siPool_1_split2, technical replicate, 72h |
| GSM3525940 |
EW1_siPool_2_split1, technical replicate, 72h |
| GSM3525941 |
EW1_siPool_2_split2, technical replicate, 72h |
| GSM3525942 |
POE_siCTR_split1, technical replicate, 72h |
| GSM3525943 |
POE_siCTR_split2, technical replicate, 72h |
| GSM3525944 |
POE_siPool_1_split1, technical replicate, 72h |
| GSM3525945 |
POE_siPool_1_split2, technical replicate, 72h |
| GSM3525946 |
POE_siPool_2_split1, technical replicate, 72h |
| GSM3525947 |
POE_siPool_2_split2, technical replicate, 72h |
| GSM3525948 |
RDES_siCTR_split1, technical replicate, 72h |
| GSM3525949 |
RDES_siCTR_split2, technical replicate, 72h |
| GSM3525950 |
RDES_siPool_1_split1, technical replicate, 72h |
| GSM3525951 |
RDES_siPool_1_split2, technical replicate, 72h |
| GSM3525952 |
RDES_siPool_2_split1, technical replicate, 72h |
| GSM3525953 |
RDES_siPool_2_split2, technical replicate, 72h |
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| Relations |
| BioProject |
PRJNA511006 |
| SRA |
SRP174102 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE124221_EW1-siPool1_vs_EW1-Control.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| GSE124221_EW1-siPool2_vs_EW1-Control.txt.gz |
1.3 Mb |
(ftp)(http) |
TXT |
| GSE124221_Normalized_counts.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| GSE124221_POE-siPool1_vs_POE-Control.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| GSE124221_POE-siPool2_vs_POE-Control.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
| GSE124221_RDES-siPool1_vs_RDES-Control.txt.gz |
1.7 Mb |
(ftp)(http) |
TXT |
| GSE124221_RDES-siPool2_vs_RDES-Control.txt.gz |
1.7 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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