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Series GSE124176 Query DataSets for GSE124176
Status Public on Jun 25, 2019
Title HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary We investigated whether the cardioprotective effect of HDL modulates miRNAs as a downstream target of STAT3 activation.
Overall design miRNAs profile was analysed by microarray. The analysis was divided in 6 groups: 3 experimental protocols (sham=no ischemia, IR=ischemia reperfusion protocol and IR+HDL= ischemia reperfusion protocol, treated with HDL at the onset of reperfusion) and 2 mouse genotype (WT=willd type, STAT3_KO=STAT3 cardiac-restricted KO). This microarray analysis includes 3 mice per group.
Contributor(s) Pedretti S, Brulhart-Meynet M, Montecucco F, Lecour S, James RW, Frias MA
Citation(s) 31220137
Submission date Dec 20, 2018
Last update date Jun 25, 2019
Contact name Celine Delucinge
Organization name University of Geneva
Department iGE3 Genomics Platform
Street address 1 rue Michel Servet
City Geneva
ZIP/Postal code 1211
Country Switzerland
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (18)
GSM3523412 STAT3_KO_IR_22
GSM3523413 STAT3_KO_IR+HDL_23
GSM3523414 STAT3_KO_IR+HDL_24
BioProject PRJNA510950

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124176_RAW.tar 13.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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