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| Status |
Public on May 20, 2020 |
| Title |
Expression data from OMP52M51 resistant or acute treated leukemic mice |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We recently demonstrated that a human Notch1-specific neutralizing antibody (OMP52M51) was very effective in T-ALL patient derived xenografts (PDX) bearing NOTCH1/FBW7 mutations. However, we observed development of acquired resistance following long-term administration of the antibody and used PDX models to investigate this phenomenon.
We analyzed expression profiles to identify genes and pathways modulated in mice treated until progression or acute treated with a neutralizing antibody against Notch1.
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| Overall design |
Cells were recovered from spleens of control (Ctrl Ab), resistant (OMP52M51 resistant) or acute treated (acute) mice for RNA extraction and hybridization on Affymetrix microarrays. Each sample derived from a different mouse (3-5 mice/group).
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| Contributor(s) |
Agnusdei V, Minuzzo S, Amaro A |
| Citation(s) |
31467126 |
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| Submission date |
Dec 12, 2018 |
| Last update date |
May 20, 2020 |
| Contact name |
Valentina Agnusdei |
| E-mail(s) |
valentina.agnusdei@gmail.com
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| Organization name |
Istituto Oncologico Veneto
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| Street address |
Via Gattamelata, 64
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| City |
Padova |
| State/province |
PD |
| ZIP/Postal code |
35128 |
| Country |
Italy |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (20)
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| GSM3755091 |
PDTALL19 model, control group, mouse #1 |
| GSM3755092 |
PDTALL19 model, control group, mouse #2 |
| GSM3755093 |
PDTALL19 model, control group, mouse #3 |
| GSM3755094 |
PDTALL19 model, control group, mouse #4 |
| GSM3755095 |
PDTALL19 model, control group, mouse #5 |
| GSM3755096 |
PDTALL19 model, OMP52M51 resistant, mouse #1 |
| GSM3755097 |
PDTALL19 model, OMP52M51 resistant, mouse #2 |
| GSM3755098 |
PDTALL19 model, OMP52M51 resistant, mouse #3 |
| GSM3755099 |
PDTALL19 model, OMP52M51 resistant, mouse #4 |
| GSM3755100 |
PDTALL19 model, acute treated with OMP52M51, mouse #1 |
| GSM3755101 |
PDTALL19 model, acute treated with OMP52M51, mouse #2 |
| GSM3755102 |
PDTALL19 model, acute treated with OMP52M51, mouse #3 |
| GSM3755103 |
PDTALL19 model, acute treated with OMP52M51, mouse #4 |
| GSM3755104 |
PDTALL19 model, acute treated with OMP52M51, mouse #5 |
| GSM3755105 |
PDTALL8 model, control group, mouse #1 |
| GSM3755106 |
PDTALL8 model, control group, mouse #2 |
| GSM3755107 |
PDTALL8 model, control group, mouse #3 |
| GSM3755108 |
PDTALL8 model, OMP52M51 resistant, mouse #1 |
| GSM3755109 |
PDTALL8 model, OMP52M51 resistant, mouse #2 |
| GSM3755110 |
PDTALL8 model, OMP52M51 resistant, mouse #3 |
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| Relations |
| BioProject |
PRJNA509685 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE123751_RAW.tar |
499.7 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data provided as supplementary file |
| Processed data included within Sample table |
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