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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 13, 2018 |
| Title |
RNA-seq of Splenic CD4+ T cells and colon epithelial cells from miR-34a-/- and wildtype mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
miR-34a is a known tumor suppressor that targets cell proliferation and apoptosis genes. In this study, we have shown that miR-34a acts as a safeguard for the inflammatory stem cell niche and reparative regeneration by modulating both the immune and epithelial responses to infection and inflammation. We isolated CD4+ T cells and colon epithelial cells from miR-34a-/- and wildtype mice revealed various changes in gene expression.
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| Overall design |
CD4+ T cells and colon epithelial cells are isolated from miR-34a-/- and wildtype mice, each with 3 replicates
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| Contributor(s) |
Wang L, Wang E, Wang Y, Mines R, Xiang K, Sun Z, Zhou G, Chen K, Rakhilin N, Chao S, Ye G, Wu Z, Yan H, Shen H, Everitt J, Bu P, Shen X |
| Citation(s) |
30543324 |
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| Submission date |
Dec 11, 2018 |
| Last update date |
Mar 19, 2019 |
| Contact name |
Ergang Wang |
| E-mail(s) |
ew152@duke.edu
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| Organization name |
Duke University
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| Department |
PCB
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| Lab |
Xiao-fan Wang
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| Street address |
C215, LSRC
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| City |
Durham |
| State/province |
NC |
| ZIP/Postal code |
27708 |
| Country |
USA |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA509684 |
| SRA |
SRP173351 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE123628_RAW.tar |
2.1 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE123628_gene_names.txt.gz |
295.0 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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