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Series GSE123377 Query DataSets for GSE123377
Status Public on Jul 14, 2020
Title Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile [miRNA]
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Currently it is unknown whether activation of recruited or resident pancreatic fibroblasts, including pancreatic stellate cells activation, create a common “fibroblast-activated phenotype” indistinguishable from their associated-diseased microenvironment . Using a combination of microRNA and mRNA profiling of fibroblasts isolated from pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), periampullary cancer (PAT) and areas of histologically normal pancreas, followed by comprehensive validation, we show that activated fibroblasts derived from different pancreatic disease types are considerably distinct.
 
Overall design Total RNA from primary cultures of activated fibroblasts isolated from human PDAC (n=6), CP (n=5), PAT (n=5) and adjacent normal tissue (n=5) was hybridized onto Affymetrix GeneChip miRNA 4.0 arrays.
 
Contributor(s) Lane B, Barrera L, Costello E
Citation(s) 32393661
Submission date Dec 05, 2018
Last update date Jul 14, 2020
Contact name Eithne Costello
E-mail(s) ecostell@liverpool.ac.uk
Organization name University of Liverpool
Department Department of Molecular and Clinical Cancer Medicine
Street address Ashton Street
City Liverpool
ZIP/Postal code L69 3GE
Country United Kingdom
 
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (27)
GSM3502388 miRNA CP fibroblast IMDM Biological rep 1
GSM3502389 miRNA CP fibroblast IMDM Biological rep 2
GSM3502390 miRNA CP fibroblast IMDM Biological rep 3
This SubSeries is part of SuperSeries:
GSE123378 Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile
Relations
BioProject PRJNA508534

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE123377_RAW.tar 19.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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