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Series GSE122834 Query DataSets for GSE122834
Status Public on Feb 12, 2019
Title Roles of HDAC1 and HDAC2 in the developing mouse brain
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In this study, we investigated the role of HDAC1 and HDAC2 in the developing mouse brain. We found that the removal of HDAC1 and HDAC2 caused severe malformation. To examine the molecular mechanisms underlying the cortical malformation, we examined the transcriptome in both WT and HDAC1/2 deficient brains. We found that many genes that are associated with transcription were misregulated in HDAC1 and HDAC2 mutant brains. This result provides a resource for studying gene expression controlled by HDAC1 and HDAC2.
Overall design Mouse embryonic for brains were isolated from E12.5 embryos. Total RNAs were extracted using Trizol reagent and applied for RNA sequencing subsequently.
Contributor(s) Tang T, Xie Y
Citation(s) 30709655
Submission date Nov 21, 2018
Last update date Jul 06, 2019
Contact name Yunli Xie
Organization name Fudan University
Department Institutes of Brain Science
Lab Xie Lab
Street address 131 Dong'an Road, Shanghai
City Shanghai
State/province Shanghai
ZIP/Postal code 200032
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (6)
GSM3486705 WT rep1
GSM3486706 WT rep2
GSM3486707 WT rep3
BioProject PRJNA506452
SRA SRP170067

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE122834_processed_data.txt.gz 907.7 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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