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| Status |
Public on Feb 05, 2019 |
| Title |
Genetic AMPK activation in liver protects against diet-induced obesity and NAFLD |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We developed a GEMM in which AMPK can be inducibly activated in vivo (iAMPK mice). We provide here the data (RNA seq) on the transcriptional changes induced by AMPK activation in livers from mice fed a high-fat diet.
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| |
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| Overall design |
iAMPK and L-iAMPK mice were fed a high-fat diet (45% calories from fat), plus or minus doxycycline, for eight weeks before collection of liver samples. Doxycycline-treated L-iAMPK mice activate AMPK in liver.
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| |
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| Contributor(s) |
Garcia D, Shokhirev MN, Shaw RJ |
| Citation(s) |
30605676 |
| |
| Submission date |
Nov 20, 2018 |
| Last update date |
Mar 28, 2022 |
| Contact name |
April Elizabeth Williams |
| E-mail(s) |
apriljack06@gmail.com, awilliams@salk.edu
|
| Phone |
7345461645
|
| Organization name |
Salk Institute for Biological Studies
|
| Department |
IGC
|
| Street address |
10010 N Torrey Pines Rd
|
| City |
San Diego |
| State/province |
California |
| ZIP/Postal code |
92037 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA506251 |
| SRA |
SRP169946 |
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