|
| Status |
Public on Nov 10, 2018 |
| Title |
DNA methylation in AgRP neurons regulates voluntary exercise behaviour in mice |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
Expression profiling by high throughput sequencing
|
| Summary |
Knock out of Dnmt3a in AgRP neurons leads to a sedentary, adiposity-prone adult phenotype associated with widespread changes in DNA methylation and gene expression.
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| |
|
| Overall design |
Genome-wide bisulfite-seq and RNA-Seq of FACS-sorted neural (NeuN+) nuclei from the arcuate nucleus of the hypothalamus.
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| |
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| Contributor(s) |
MacKay H, Scott CA, Duryea JD, Baker MS, Larisky E, Elson AE, Garland T Jr, Fiorotto ML, Chen R, Li Y, Coarfa C, Simerly RB, Wateland RA |
| Citation(s) |
31792207 |
| |
| Submission date |
Nov 09, 2018 |
| Last update date |
Dec 10, 2019 |
| Contact name |
Harry MacKay |
| Organization name |
Baylor College of Medicine
|
| Street address |
1100 Bates Ave
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (16)
|
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| Relations |
| BioProject |
PRJNA504907 |
| SRA |
SRP168393 |
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