Expression profiling by high throughput sequencing
Summary
Male Sprague Dawley rats were treated orally for 5 days with reference hepatotoxicants, each at a single dose level, alpha-naphthylisothiocyanate 100mg/kg (vehicle 5ml/kg corn oil); carbon tetrachloride 1582mg/kg (vehicle 5ml/kg corn oil); methylenedianiline 100mg/kg (vehicle 35% ethanol); acetaminophen 1000mg/kg (vehicle 2ml/kg corn oil); diclofenac 10mg/kg (vehicle 10ml/kg water)
Overall design
3 rats were treated with each hepatotoxicant, 3 rats were treated with corresponding vehicle for each hepatotoxicant, total RNA was isolated form left lateral lobe of liver of all rats, samples run individually on Affymetrix GeneChip Rat Genome 230_2.0 Arrays
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