|
| Status |
Public on Jan 17, 2019 |
| Title |
Estrogen Signaling in Arcuate Kiss1 Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: To characterize the estrogen receptor α (ESR1)-dependent transcriptome of neurons in the arcuate nucleus that regulate female bone density
|
| |
|
| Overall design |
Method: Using RNA-Seq we compared gene expression profiles of microdissected arcuate nuclei from 3 control (Esr1fl/fl) and 3 conditional knockout (Esr1fl/fl;Nkx2-1-Cre) female mice.
|
| |
|
| Contributor(s) |
Krause WC, Ingraham HA |
| Citation(s) |
30635563 |
| |
| Submission date |
Nov 07, 2018 |
| Last update date |
Mar 19, 2019 |
| Contact name |
Holly A Ingraham |
| E-mail(s) |
holly.ingraham@ucsf.edu
|
| Organization name |
University of California, San Francisco
|
| Department |
Cellular and Molecular Pharmacology
|
| Street address |
1550 4th Street, 284F
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (6)
|
| GSM3463523 |
Conditional Knockout Rep. 1 (Esr1fl/fl;Nkx2-1-Cre) |
| GSM3463524 |
Conditional Knockout Rep. 2 (Esr1fl/fl;Nkx2-1-Cre) |
| GSM3463525 |
Conditional Knockout Rep. 3 (Esr1fl/fl;Nkx2-1-Cre) |
|
| Relations |
| BioProject |
PRJNA504469 |
| SRA |
SRP168132 |
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