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Series GSE121882 Query DataSets for GSE121882
Status Public on Jan 23, 2019
Title Unregulated APC activation by T cells breaks self-tolerance
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The absence of nTregs results in slight increase of B7 on dendritic cells (DC). Such slightly elevated B7 induce proliferation of T cells with intrinic high self-affinity: bidirectional T/DC interaction ensues, leading to progressive DC activation and reciprocal strong T cell activation.
Overall design mRNA were purified from lymph node or spleen dendritic cells of germ-free Rag KO mice adoptively transferred with FACS-purifed naïve CD4 T cells or Tregs before a week.
Contributor(s) Yi J, Jung J, Hong S, Han D, Surh CD
Citation(s) 30598454
Submission date Oct 26, 2018
Last update date Jan 27, 2019
Contact name Jaeu Yi
Organization name POSTECH
Street address Cheongamro77
City Pohang
ZIP/Postal code 37673
Country South Korea
Platforms (1)
GPL16417 Illumina MiSeq (Mus musculus)
Samples (6)
GSM3449416 PLN DC of un-injected GF Rag KO mice
GSM3449417 PLN DC of GF Rag KO mice injected with naïve CD4 T cells
GSM3449418 PLN DC of GF Rag KO mice injected with Tregs
BioProject PRJNA498714
SRA SRP166995

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Supplementary file Size Download File type/resource
GSE121882_2017BS039_RNA-Seq_Result_DiffExpGenes.xlsx 24.1 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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