|
| Status |
Public on Jan 23, 2019 |
| Title |
Unregulated APC activation by T cells breaks self-tolerance |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The absence of nTregs results in slight increase of B7 on dendritic cells (DC). Such slightly elevated B7 induce proliferation of T cells with intrinic high self-affinity: bidirectional T/DC interaction ensues, leading to progressive DC activation and reciprocal strong T cell activation.
|
| |
|
| Overall design |
mRNA were purified from lymph node or spleen dendritic cells of germ-free Rag KO mice adoptively transferred with FACS-purifed naïve CD4 T cells or Tregs before a week.
|
| |
|
| Contributor(s) |
Yi J, Jung J, Hong S, Han D, Surh CD |
| Citation(s) |
30598454 |
| |
| Submission date |
Oct 26, 2018 |
| Last update date |
Jan 27, 2019 |
| Contact name |
Jaeu Yi |
| E-mail(s) |
discount73@gmail.com
|
| Organization name |
POSTECH
|
| Street address |
Cheongamro77
|
| City |
Pohang |
| ZIP/Postal code |
37673 |
| Country |
South Korea |
| |
|
| Platforms (1) |
|
| Samples (6)
|
| GSM3449416 |
PLN DC of un-injected GF Rag KO mice |
| GSM3449417 |
PLN DC of GF Rag KO mice injected with naïve CD4 T cells |
| GSM3449418 |
PLN DC of GF Rag KO mice injected with Tregs |
| GSM3449419 |
spleen DC of un-injected GF Rag KO mice |
| GSM3449420 |
spleen DC of GF Rag KO mice injected with naïve CD4 T cells |
| GSM3449421 |
spleen DC of GF Rag KO mice injected with Tregs |
|
| Relations |
| BioProject |
PRJNA498714 |
| SRA |
SRP166995 |
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