|
| Status |
Public on Jan 01, 2019 |
| Title |
C5aR1 regulates T-follicular-helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of the study was to determine the effect of T cell expressed C5ar1 on transcriptional profiles of in vivo generated allogeneic T follicular helper cells
|
| |
|
| Overall design |
10 million CD8 depleted spleen cells from WT or C5aR1-deficient donors were injected into (bxd)F1 recipients and 7 days later donor CXCR5, PD1hi cells were flow sorted and sequenced. Side by side control samples of naïve WT and C5ar1 deficient CD4 cells were included
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| |
|
| Contributor(s) |
Zhang W, Yi Z, Heeger PS |
| Citation(s) |
30568034 |
| |
| Submission date |
Oct 25, 2018 |
| Last update date |
Apr 02, 2019 |
| Contact name |
Weijia Zhang |
| E-mail(s) |
weijia.zhang@mssm.edu
|
| Organization name |
Icahn School of Medicine at Mount Sinai
|
| Department |
Renal
|
| Lab |
Bioinfomatics
|
| Street address |
1 Gustave L. Levy Pl
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA498508 |
| SRA |
SRP166980 |
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