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| Status |
Public on Feb 13, 2019 |
| Title |
Inhibition of YAP in human HCC cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In vertebrates, the evolutionary conserved Hippo pathway fine-tunes organ size under physiological conditions such as tissue regeneration through the transcriptional regulation of pro-proliferative and anti-apoptotic genes. Here we want to identify downstream effectors of YAP, which is the most important transcriptional activator of this pathway.
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| Overall design |
Nonsense/Scrambled siRNA-transfected and gene-specific siRNAs (YAP1, YAP2) were transently transfected in HepG2 cells (20 nM each). Total mRNA was extracted 24 hours after transfection.
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| Contributor(s) |
Sticht C, Breuhahn K |
| Citation(s) |
30936457 |
| |
| Submission date |
Oct 24, 2018 |
| Last update date |
Apr 30, 2019 |
| Contact name |
Carsten Sticht |
| Organization name |
University Heidelberg
|
| Department |
ZMF
|
| Street address |
Theodor-Kutzer-Ufer
|
| City |
Mannheim |
| ZIP/Postal code |
68169 |
| Country |
Germany |
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| Platforms (1) |
| GPL20103 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [CDF: hugene20st_Hs_ENTREZG.cdf, Brainarray version 19.0.0] |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA498280 |
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