|
| Status |
Public on Apr 18, 2019 |
| Title |
Quizalofop-p-ethyl induces adipogenesis in 3T3-L1 cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We provide here the alterations in gene expression profiles of 3T3-L1 cells, a validated model for adipogenesis, exposed to quizalofop-p-ethyl for 6h, 24h and 12 days.
|
| |
|
| Overall design |
Exposure to endocrine disrupting chemicals is a risk factor for obesity. The most commonly used pesticide active ingredients have never been tested in an adipogenesis assay. We tested for the first time the lipid accumulation induced by glyphosate, 2,4-dichlorophenoxyacetic acid, dicamba, mesotrione, isoxaflutole and quizalofop-p-ethyl (QpE) in 3T3-L1 adipocytes. Only QpE caused triglyceride accumulation from a concentration of 1 µM. We thus conducted an in-depth investigation of molecular mechanisms responsible for the adipogenic effects of quizalopfop-p-ethyl by an RNA-seq analysis.
|
| Web link |
https://academic.oup.com/toxsci/advance-article/doi/10.1093/toxsci/kfz097/5472348?searchresult=1
|
| |
|
| Contributor(s) |
Mesnage R, Mein CA |
| Citation(s) |
31086981 |
| |
| Submission date |
Oct 17, 2018 |
| Last update date |
Aug 21, 2019 |
| Contact name |
Robin Mesnage |
| E-mail(s) |
robinmes@gmail.com
|
| Phone |
+447482206767
|
| Organization name |
Kings College London
|
| Street address |
Guy's Hospital, 8th Floor, Tower Wing
|
| City |
London |
| ZIP/Postal code |
SE1 9RT |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (30)
|
|
| Relations |
| BioProject |
PRJNA497292 |
| SRA |
SRP166017 |
Less...
More...