|
| Status |
Public on Jun 17, 2019 |
| Title |
Liver lncRNA gene expression in response to CAR/PXR agonists |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Gene expression in livers of male and female mice treated with the CAR agonist ligand TCPOBOP or the PXR agonist ligand PCN
|
| |
|
| Overall design |
RNA-Seq was performed on liver RNA isolated from individual mice 3 hr or 6 hr after treatment with TCPOBOP or PCN. The corresponding untreated mice livers were included in GEO series GSE66140, namely GSM1612431 (liver G81_M1) as control for G81_M3 and G81_M5; GSM1612432 (liver G81_M2) as control for G81_M4 and G81_M6; GSM1612433 (liver G81_M7) as control for G81_M9 and G81_M10; samples GSM1612759-GSM1612761 for the G86 series; and samples GSM1612774-GSM1612776 for the G95 series.
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| |
|
| Contributor(s) |
Lodato NJ, Melia T, Waxman DJ |
| Citation(s) |
28903501 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 ES024421 |
Epigenetic Actions of Environmental Chemicals |
BOSTON UNIVERSITY CHARLES RIVER CAMPUS |
DAVID J WAXMAN |
|
| |
| Submission date |
Oct 04, 2018 |
| Last update date |
Jun 17, 2019 |
| Contact name |
David J. Waxman |
| E-mail(s) |
djw@bu.edu
|
| Organization name |
Boston University
|
| Department |
Department of Biology and Bioinformatics Program
|
| Street address |
5 Cummington Mall
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (12)
|
| GSM3417054 |
TCPOBOP-treated (mice euthanized 3 hr after injection, at 11 AM)_G81_M3 |
| GSM3417055 |
TCPOBOP-treated (mice euthanized 6 hr after injection, at 2 PM)_G81_M4 |
| GSM3417056 |
PCN-treated (mice euthanized 3 hr after injection, at 11 AM)_G81_M5 |
| GSM3417057 |
PCN-treated (mice euthanized 6 hr after injection, at 2 PM)_G81_M6 |
| GSM3417058 |
TCPOBOP-treated (mice euthanized 3 hr after injection, at 11 AM)_G81_M9 |
| GSM3417059 |
PCN-treated (mice euthanized 3 hr after injection, at 11 AM)_G81_M10 |
| GSM3417060 |
TCPOBOP-treated pool 1 (mice euthanized 3 hr after injection, at 11 AM)_G86_M4 |
| GSM3417061 |
TCPOBOP-treated pool 2 (mice euthanized 3 hr after injection, at 11 AM)_G86_M5 |
| GSM3417062 |
TCPOBOP-treated pool 3 (mice euthanized 3 hr after injection, at 11 AM)_G86_M6 |
| GSM3417063 |
TCPOBOP-treated pool 1 (mice euthanized 3 hr after injection, at 11 AM)_G95_M4 |
| GSM3417064 |
TCPOBOP-treated pool 2 (mice euthanized 3 hr after injection, at 11 AM)_G95_M5 |
| GSM3417065 |
TCPOBOP-treated pool 3 (mice euthanized 3 hr after injection, at 11 AM)_G95_M6 |
|
| Relations |
| Reanalysis of |
GSM1612431 |
| Reanalysis of |
GSM1612432 |
| Reanalysis of |
GSM1612433 |
| Reanalysis of |
GSM1612759 |
| Reanalysis of |
GSM1612760 |
| Reanalysis of |
GSM1612761 |
| Reanalysis of |
GSM1612774 |
| Reanalysis of |
GSM1612775 |
| Reanalysis of |
GSM1612776 |
| BioProject |
PRJNA494727 |
| SRA |
SRP163497 |
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