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| Status |
Public on Oct 02, 2018 |
| Title |
Differential analysis of gene expression profiles in peripheral blood cells of patients with cervical lesions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using RNA-sequencing analysis of peripheral blood cells from 11 cervical cancer patients, 21 cervical intraepithelial neoplasia patients and 19 healthy controls, we identified a group of differentially expressed genes. A real time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was applied to the validation of candidate markers in the blood of 115 patients and 46 healthy controls. The results suggest that a six-gene predictor set (GZMB, NDUFA1, GPR84, NUAK1, AGAP1 and CIR1) can be used as candidate genes for the detection of cervical cancer.
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| Overall design |
The mRNA profiles of peripheral blood cells from 11 cervical cancer patients, 21 cervical intraepithelial neoplasia patients and 19 healthy control participants were sequenced using Illumina 2500.
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| Contributor(s) |
Ma Q, Shao Y, Zhou Z, Wang S |
| Citation(s) |
32064895 |
| |
| Submission date |
Oct 01, 2018 |
| Last update date |
Apr 09, 2020 |
| Contact name |
Yong Shao |
| E-mail(s) |
281298681@qq.com
|
| Phone |
15701120654
|
| Organization name |
Beijing Institute of Radiation Medicine
|
| Street address |
27 Taiping Road
|
| City |
Beijing |
| ZIP/Postal code |
100850 |
| Country |
China |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (51)
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| Relations |
| BioProject |
PRJNA494155 |
| SRA |
SRP163027 |
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