 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Aug 19, 2019 |
| Title |
Molecular singularities in a pheromone sensor triumvirate desynchronize the competence-predation interplay in the human commensal Streptococcus salivarius |
| Organism |
Streptococcus salivarius |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The human oral cavity is one of the most competing environments, considering the extent and diversity of the bacterial community that colonizes it, as well as the multiple stresses to which it is subjected. The commensal species Streptococcus salivarius is one of the first colonizers of the oral mucosa (tongue, gums, inner cheeks and tooth enamel) in infants and remains predominant throughout the life of an adult. In order to adapt to diverse and variable environmental conditions, S. salivarius triggers in a coordinated way two bacterial developmental processes: competence (acquisition of extracellular DNA and new genetic traits) and predation (secretion of cytotoxic molecule), via ComR, a transcription factor activatable by a "pheromone" peptide. Nevertheless, the activation of other transcriptional regulators can uncouple these 2 mechanisms to allow, for example, only the production of toxins without triggering the competence phase.
|
| |
|
| Overall design |
Examination of mRNA transcriptional profiles in WT and 2 deletion and 2 overexpression mutant strains.
|
| |
|
| Contributor(s) |
Mignolet J, Cerckel G, Damoczi J, Ledesma-Garcia L, Coenye T, Hols P |
| Citation(s) |
31433299 |
| |
| Submission date |
Sep 28, 2018 |
| Last update date |
Aug 27, 2019 |
| Contact name |
Johann Mignolet |
| E-mail(s) |
johann.mignolet@unil.Ch
|
| Organization name |
UNIL
|
| Department |
DMF
|
| Lab |
Veening lab
|
| Street address |
Biophore Quartier UNIL-SORGE
|
| City |
Lausanne |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL23620 |
Illumina NextSeq 500 (Streptococcus salivarius) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA493819 |
| SRA |
SRP162871 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE120640_Table_S1.xlsx |
313.5 Kb |
(ftp)(http) |
XLSX |
| GSE120640_Table_S2.xlsx |
312.8 Kb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...