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| Status |
Public on Oct 25, 2018 |
| Title |
A mechanistic classification of clinical phenotypes in neuroblastoma (telomere maintenance cohort) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Our study proposes a precise mechanistic classification of clinical neuroblastoma phenotypes that is based on telomere maintenance mechanisms and RAS or p53 pathway mutations. A crucial factor in telomere maintenance is overexpression of TERT. We therefore determined a TERT expression threshold to identify MYCN-WT TERT-WT tumors whose TERT mRNA levels are comparable to those of tumors bearing MYCN or TERT alterations.
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| Overall design |
Single-color gene expression profiles from 208 neuroblastoma tumors were generated using 44K oligonucleotide microarrays. Stages were classified according to the International Neuroblastoma Staging System.
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| Contributor(s) |
Fischer M, Bartenhagen C |
| Citation(s) |
30523111 |
| |
| Submission date |
Sep 27, 2018 |
| Last update date |
Jan 24, 2019 |
| Contact name |
Matthias Fischer |
| E-mail(s) |
matthias.fischer@uk-koeln.de
|
| Organization name |
University Children’s Hospital of Cologne
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| Department |
Department of Experimental Pediatric Oncology
|
| Street address |
Kerpener Str. 62
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| City |
Cologne |
| ZIP/Postal code |
50937 |
| Country |
Germany |
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| Platforms (1) |
| GPL16876 |
Agilent-020382 Human Custom Microarray 44k (Feature Number version) |
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| Samples (208)
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| This SubSeries is part of SuperSeries: |
| GSE120572 |
A mechanistic classification of clinical phenotypes in neuroblastoma |
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| Relations |
| BioProject |
PRJNA493570 |
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