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| Status |
Public on Oct 01, 2018 |
| Title |
Mouse models with defective DNA damage repair |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Chromothripsis and chromoanasynthesis are one-off catastrophic events leading to clustered genomic rearrangements.
Expression profiling were performed on brain tissues with Medulloblastoma (n=9) and normal Cerebellum (n=4) to compare the expression of Double strain break DNA repair pathways.
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| Overall design |
Chromothripsis or chromoanasynthesis were frequently observed in brain tumors in mice deficient for Homologous-Recombination-Repair or Non-Homologous-End-Joining factors. Expression profiling were performed on brain tissues with Medulloblastoma (n=9) and normal Cerebellum (n=4) to compare the expression of Double strain break DNA repair pathways.
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| |
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| Contributor(s) |
Manasi R, Wong JK |
| Citation(s) |
30420702 |
| |
| Submission date |
Sep 23, 2018 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Kwong Leong Wong |
| E-mail(s) |
wkljohn@gmail.com
|
| Organization name |
DKFZ
|
| Department |
Molecular genetics
|
| Street address |
Im Neuenheimer Feld 280
|
| City |
Heidelberg |
| State/province |
Germany (DEU) |
| ZIP/Postal code |
69120 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA492800 |
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