|
| Status |
Public on Aug 09, 2019 |
| Title |
N6-methyladenosine (m6A) profiling of type II diabetes islets |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
In type 2 diabetes, pancreatic beta-cells fail to compensate for the presence of insulin resistance in target tissues and represent a central player in the disease development. Identifying and studying innovative molecular mechanisms that lead to beta-cell failure in diabetes represent an interesting line of research and are necessary. N6-Methyladenosine (m6A) is the most abundant modification in mRNA and is found virtually in all mammals. Through m6A-profiling, we aim to characterize the dynamic RNA methylation changes in islets obtained from patients with type 2 diabetes.
|
| |
|
| Overall design |
MeRIP-seq profiling of T2D islets
|
| Web link |
https://www.nature.com/articles/s42255-019-0089-9
|
| |
|
| Contributor(s) |
Zhang Z, DeJesus D, Kulkarni R, He C |
| Citation(s) |
31867565 |
| |
| Submission date |
Sep 17, 2018 |
| Last update date |
Feb 11, 2022 |
| Contact name |
Zijie Zhang |
| E-mail(s) |
scottzjzhang@uchicago.edu
|
| Phone |
7738083212
|
| Organization name |
University of Chicago
|
| Department |
Chemistry
|
| Lab |
He, Chuan
|
| Street address |
919E 57th
|
| City |
CHICAGO |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (30)
|
|
| Relations |
| BioProject |
PRJNA491415 |
| SRA |
SRP161883 |
Less...
More...