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| Status |
Public on Apr 09, 2019 |
| Title |
Temporal dynamic reorganization of 3D chromatin in hormone-induced breast cancer and endocrine resistance [T47D] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
To establish a data-driven learning model of the temporal dynamics and 3D chromatin reorganization, we conducted tethered chromatin conformation (TCC) sequencing to examine 3D structure dynamics in estradiol (E2)-induced breast cancer T47D cells and Tamoxifen resistant breast cancer T47D cells.
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| Overall design |
In this study, we conducted TCC analysis in hormone-starved T47D cells (T0) and compared this to T47D cells treated with 1hr of E2 (T1), 4hr of E2 (T4), 16hr of E2 (T16), 24hr of E2 (T24) and Tamoxifen resistant T47D cells. We could investigate dynamic 3D chromatin architecture in T47D cell lines from these TCC data.
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| Contributor(s) |
Zhou Y, Jin V |
| Citation(s) |
30944316 |
| |
| Submission date |
Sep 13, 2018 |
| Last update date |
Apr 09, 2019 |
| Contact name |
Yufan Zhou |
| Organization name |
UT health Science Center at San Antonio
|
| Street address |
7703 Floyd Curl Dr
|
| City |
San Antonio |
| State/province |
TX |
| ZIP/Postal code |
78229 |
| Country |
USA |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA490630 |
| SRA |
SRP161662 |
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