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Status |
Public on Jan 01, 2019 |
Title |
Molecular Pathology of adverse local tissue reaction caused by metal-on-metal implants |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
RNA-sequencing analysis of periacetabular synovial tissue collected from patients undergoing a revision total hip arthroplasty (rTHA) after failure of a Cobalt Chromium implant. Comparisons were made to periacetabular synovial tissue collected from patients undergoing primary THAs (pTHA). Results: Analysis of tissue biopsies by RNA-sequencing revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling.
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Overall design |
RNA was extracted from 3 pTHA and 3 rTHA samples and used for RNA-sequencing. Comparative analysis was performed using RPKM values obtained after processing of sequencing data.
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Contributor(s) |
Abdel MP, van Wijnen AJ |
Citation missing |
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Submission date |
Aug 31, 2018 |
Last update date |
Mar 21, 2019 |
Contact name |
Asha Nair |
E-mail(s) |
nair.asha@mayo.edu
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Organization name |
Mayo Clinic
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Street address |
200 1ST ST SW
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City |
Rochester |
ZIP/Postal code |
55901 |
Country |
USA |
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Platforms (1) |
GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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Samples (6)
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Relations |
BioProject |
PRJNA488798 |
SRA |
SRP159261 |