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| Status |
Public on Jan 01, 2019 |
| Title |
Molecular Pathology of adverse local tissue reaction caused by metal-on-metal implants |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA-sequencing analysis of periacetabular synovial tissue collected from patients undergoing a revision total hip arthroplasty (rTHA) after failure of a Cobalt Chromium implant. Comparisons were made to periacetabular synovial tissue collected from patients undergoing primary THAs (pTHA).
Results: Analysis of tissue biopsies by RNA-sequencing revealed that MoM patient samples exhibit significantly increased expression of immune response genes but decreased expression of genes related to extracellular matrix (ECM) remodeling.
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| Overall design |
RNA was extracted from 3 pTHA and 3 rTHA samples and used for RNA-sequencing. Comparative analysis was performed using RPKM values obtained after processing of sequencing data.
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| Contributor(s) |
Abdel MP, van Wijnen AJ |
| Citation missing |
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| |
| Submission date |
Aug 31, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Asha Nair |
| E-mail(s) |
nair.asha@mayo.edu
|
| Organization name |
Mayo Clinic
|
| Street address |
200 1ST ST SW
|
| City |
Rochester |
| ZIP/Postal code |
55901 |
| Country |
USA |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA488798 |
| SRA |
SRP159261 |
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