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Series GSE119122 Query DataSets for GSE119122
Status Public on Sep 11, 2018
Title Transcriptomic profiles of tissues from rats treated with drug combinations [Study 1]
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Combinations of anticancer agents may have synergistic anti-tumor effects, but enhanced toxicity often limit their clinical use. The risk that combinations of two or more drugs will cause adverse effects that are more severe than drugs used as monotherpies can be hypothesized from comprehensive analysis of each compound’s activity. We generated microarray gene expression data following a single dose of agents administered individually with that of the agents administered in a combination. The key objective of this initiative is to generate and make publicly available key high-content gene expression data sets for mechanistic hypothesis generation for several anticancer drug combinations. The expectation is that availability of tissue-based genomic information that are derived from target tissues will facilitate the generation and testing of mechanistic hypotheses. The view is that availability of these data sets for bioinformaticians and other scientists will contribute to analysis of these data and evaluation of the approach.
 
Overall design Study 1 (originally study #3): Gene expression data from the bone marrow, heart and liver of Sprague-Dawley rats after after exposure to Temsirolimus at 0.3 mg/kg (i.v) or vehicle control (i.v) followed by either Sunitinib at 5 mg/kg (orally) or Sorafenib at 25 mg/kg (orally) or vehicle control (orally).
 
Contributor(s) Davis M, Bushel PR
Citation(s) 30620345
Submission date Aug 28, 2018
Last update date Jan 15, 2019
Contact name Myrtle Davis Millin
Organization name The National Cancer Institute
Street address 31 Center Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (288)
GSM3358436 TEM_vehicle (iv) followed by Sunitinib (po) in Liver for 1 hr(s) (7M79)
GSM3358437 TEM_vehicle (iv) followed by F68/PG/PEG400 (po) in Liver for 24 hr(s) (2M18)
GSM3358438 TEM_vehicle (iv) followed by sterile water (po) in Bone Marrow for 6 hr(s) (1M3)
This SubSeries is part of SuperSeries:
GSE119135 Transcriptomic profiles of tissues from rats treated with drug combinations
Relations
BioProject PRJNA488229

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE119122_RAW.tar 751.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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