GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE118169 Query DataSets for GSE118169
Status Public on Aug 07, 2019
Title Effects of olfactory-specific Bcl11b overexpression on gene expression in the main olfactory epithelium of neonatal mice.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Individual olfactory sensory neurons (OSNs) express a single odorant receptor (OR) gene from the class I or class II repertoire in mice. The mechanisms that regulate the binary fate specification of OSNs remain unknown. Here we show that the transcription factor Bcl11b, which is expressed in class II OSNs determines the OR class to be expressed in OSNs. Genetic studies provide evidence that class I is a default-fate and Bcl11b permits a class II fate by suppressing a class I-OR enhancer. These findings reveal a unique transcriptional mechanism that serves as a binary switch to select the OR class and is crucial to both the anatomical and functional organization of olfactory system.
Overall design The mRNA profiles in the main olfactory epithelium (MOE) of neonatal Control and Bcl11b-overexpressing Tg mice were generated by deep sequencing, using an Illumina MiSeq sequencer
Contributor(s) Enomoto T, Kajitani R, Itoh T, Hirota J
Citation(s) 31396576
Submission date Aug 06, 2018
Last update date Aug 16, 2019
Contact name Junji Hirota
Organization name Tokyo Institute of Technology
Department Center for Biological Resources and Informatics
Street address 4259-B63, Nagatsuta-cho
City Yokohama
State/province Kanagawa
ZIP/Postal code 226-8501
Country Japan
Platforms (1)
GPL16417 Illumina MiSeq (Mus musculus)
Samples (2)
GSM3319945 Control
GSM3319946 Bcl11b overexpression (mutant)
BioProject PRJNA484758
SRA SRP156456

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE118169_RAW.tar 1.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap